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The extended time at intermediate doses before reaching maximum provides more opportunity for the digestive system to adjust
On one hand, the cardiovascular protection afforded by SGLT2is seems to result from their beneficial hemodynamic effects, including improvement in ventricular preload (secondary to natriuresis and osmotic diuresis) and afterload (through blood pressure reduction), but also from improvement of cardiac metabolism (through the switch from utilization of glucose to ketones), inhibition of the myocardial Na + /H + exchanger, reduction of cardiac fibrosis and necrosis, reduction of proinflammatory adipokines derived from epicardial and perivascular fat, and stimulation of erythropoiesis (which can facilitate the release of oxygen to ischemic tissues) [1, 4, 14,15,16]
Rekha Kumar, endocrinologist and associate professor of clinical medicine at Weill Cornell, told NBC's Anne Thompson during an Oct
Even after licensing, NHS access would depend on guidance, indications, local pathways and, in many cases, broader health-system decisions rather than approval alone
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