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As a consequence, the main mitochondrial proteome (~1500 proteins) is encoded by the nucleus, translated in the cytosol and imported into the mitochondria through specific translocator complexes (TIM and TOM) of the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM), respectively

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IL-1, interleukin - 1 beta

These globular proteins have an N-terminal domain that consists of a mixture of alpha-helices and beta strands, while the C-terminal domain is all-helical

The GFB selectively permits passage of nanoparticles with hydrodynamic diameters 6 months) biodistribution studies for most kidney-targeted nanotherapies, making comprehensive risk assessment challenging