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In pancreatic cells, activation of these G proteincoupled receptors is primarily mediated through pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function

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This process involves mitochondrial permeability transition and transfer of certain Bcl-2 family members from the cytoplasm to the outer mitochondrial membranes [85]

The peptide demonstrates specificity in gene expression modulation, particularly affecting Egr, Nos, Srf, Vegr, Akt1, Plc, and Kras genes, which collectively regulate cell growth, proliferation, survival, and vascular development