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AT contributed in creating the figures and in the critical revision of the manuscript

Relative to the inactive GLP-1R 30 , this includes an upwards and clockwise rotation of the ECD relative to the TMD, a reorganisation of the extracellular TM regions to accommodate peptide engagement and rearrangement of a conserved central polar network to stabilise a sharp kink within the centre of TM6, which facilitates the large outward movement of this TM at the intracellular face that is required to accommodate G protein binding

Image Credit: VectorMine / Shutterstock In a recent review published in the British Journal of Pharmacology , the authors reviewed how glucagon-like peptide 1 receptor (GLP-1) agonists may reduce alcohol and drug-seeking behaviors and evaluated their potential as treatments for addictive disorders

People who should be more cautious include those with: a history of certain thyroid cancers past serious pancreas problems serious stomach emptying disorders some rare genetic conditions People who are pregnant, trying to become pregnant, or breastfeeding should also talk with their providers about the risks and benefits of staying on or starting GLP-1 treatment

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