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Bakuchiol is a plant-derived meroterpene that supports retinol-like collagen gene expression without retinol's photosensitivity or purging risk
Zivanov, J
The peptide reduces production of pro-inflammatory cytokines including IL-1, TNF-, and IL-6 while enhancing expression of anti-inflammatory mediators such as IL-10 and TGF-, creating a cytokine milieu that supports tissue repair rather than ongoing damage
Clinical risk factors have been identified but genetic factors remain undiscovered
Fewer than 5% of people report temporary numbness or tingling from the injection itself (distinct from herniation symptoms)
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