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Aggregation happens when multiple semaglutide molecules clump together, forming larger structures that cannot bind to GLP-1 receptors

Given these inconsistencies, direct interchangeability between the two modalities is not recommended, and standardized imaging protocols or regression-based conversion equations should be applied to ensure measurement comparability in longitudinal studies [16]

Topical maintenance is likely necessary regardless of initial delivery method, since the skin continuously turns over collagen