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Amgen focuses on extended-half-life and differentiated peptide or biologic approaches that may reduce injection frequency, improving adherence in home settings

Second, kidney injury in diabetes appears to be related to glomerular hyperfiltration [93, 94], which is likely related to an excessive reabsorption of sodium in the proximal tubule, leading diminished delivery of sodium to the macula densa, and (via tubuloglomerular feedback) to afferent arteriolar dilatation [95, 96]

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Science 324 , 10761080 (2009)