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These pathways are central to geroscience because dysregulated nutrient sensing, mitochondrial dysfunction, and inflammaging drive multiple age-related diseases

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Thus while UA can be influenced by environmental, notably dietary, factors, serum UA is considered to be mainly genetically determined

This episode covers the mechanism behind GLP-1-induced muscle wasting, the body composition data from STEP 1 and SURMOUNT trials, who carries the highest risk, and where the next generation of obesity pharmacology bimagrumab combinations, pemvidutide, and retatrutide's glucagon receptor pathway is trying to solve the problem