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High resolution mass spectrometry (HR-MS) was conducted by Agilent 1290 UPLC/6540 Q-TOF

43 This suggests that this mtDNA mutation is a risk factor that requires interactions with nuclear mutations, polymorphisms or epigenetics and/or environmental triggers or modulators in order for the disease phenotype to be expressed

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These may include medications with active ingredients such as semaglutide, tirzepatide, liraglutide, setmelanotide, phentermine, orlistat, and naltrexone-bupropion

Contract research organizations (CROs) use it as a standard to see how well HPLC and mass spectrometry methods work