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In vitro COMT inhibition assays demonstrated that the tolcapone-loaded PLGA nanoparticles achieved comparable enzyme inhibition efficacy to free tolcapone, confirming therapeutic retention which was achieved in addition to a controlled-release profile and reduced cytotoxicity

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Insulin resistance and cancer: the role of insulin and IGFs

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Treatment paths 1- 4 were consecutively conducted, with safety assessments following each treatment path

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Interleukin-18 as an In Vivo Mediator of Monocyte Recruitment in Rodent Models of Rheumatoid Arthritis

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Preparative synthesis of 2 coupled with an ATP regeneration system afforded nearly the same yields 60 (Supplementary Fig

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