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In humans, 26 weeks of exenatide reduced brain response to alcohol cues in the ventral tegmental area 19
The upcoming SURMOUNT-MAINTAIN trial, expected to report results around mid-2026, will specifically compare the 5 mg maintenance dose against higher doses for weight maintenance after initial loss
Brighten on Episode 69: women on semaglutide plus HRT lost significantly more weight at every timepoint than semaglutide alone, with the effect persisting after adjusting for age, baseline weight, diabetes, and support services
Participants using semaglutide have reported more significant weight loss compared to those on a placebo, with effects that are sustainable over the long term
The theoretical advantage is dual-pathway GH stimulation and potentially greater elevation
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