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[4] The study has also explored the mechanistic action of the peptide

Currently in Phase 3 clinical trials, retatrutide demonstrated unprecedented weight loss of up to 24.2% at 48 weeks in the Phase 2 trial published in the New England Journal of Medicine

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In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required

But the reaction that surprises patients most is the opposite: many women describe a significant lift in mood almost antidepressant-like that they did not expect