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In rodents there is high expression of GLP-1Rs in the calcitonin-producing C-cells of the thyroid, and activation of these receptors by GLP-1RAs stimulates the adenylate cyclase pathway, leading to upregulation of calcitonin synthesis and, subsequently, hyperplasia and an increased incidence of adenomas (88)

What about ANY of the cardiometabolic data for the 104 week extension arm, especially the 4mg max tolerated dose and the placebo arm MTD

This decline doesnt happen all at once, but slowly, often unnoticed at first

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First, is weight loss continuing at the current dose