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A 2026 network meta-analysis including over 13,000 participants found that tirzepatide intervention produced significantly better results than semaglutide across multiple measures, not just weight loss, but also improvements in blood sugar control and metabolic health markers

The decision to stop should depend on whether you've achieved your health goals, whether your weight has stabilized at a lower set point, and whether you can sustain the behavioral changes that made your initial weight loss possible

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The flow through was collected and concentrated to 500 L using a 100 kDa filter (Merck Millipore)

day 18, p = 0.007