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The Role of UbiquitinProteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease

doi: 10.1016/j.numecd.2020.05.020 361

The failure of methionine synthesis due to cobalamin deficiency may either (1) lead to an accumulation of 5-methyl-tetrahydrofolate, trapping folate in a chemical form unusable in purine synthesis (the "folate trap" hypothesis) or (2) impair methylation reactions needed to produce formyl-tetrahydrofolate, a precursor to 5,10-methylene tetrahydrofolate

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