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GLP-1 Drugs Linked to Reduced Risk of Depression and Bipolar Disorder According to a new study published in Translational Psychiatry , lifelong genetic activation of the glucagon-like peptide-1 receptor (GLP-1R) was linked with better mental well-being and significantly lower odds of major depressive disorder and bipolar disorder
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The research language also bluntly portrays a long-term journey, with the meta-analysis authors positing that weight regain is common and drug-dependent following the discontinuation of anti-obesity pharmacotherapies. And in December 2025, the WHO issued its first-ever guideline on GLP-1 therapies for obesity, explicitly framing obesity as a chronic disease requiring "comprehensive and lifelong care, recommending GLP-1 therapies for long-term use
Although captopril is rarely prescribed today, it led to the next generation of ACE inhibitors, such as enalapril, which are widely prescribed to treat high blood pressure and heart failure
Cells 12 (1), 90
