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Individuals with pre-existing conditions such as diabetes, cardiovascular disease, or a personal or family history of cancer should exercise particular caution
For older adults or those with coronary artery disease, lower starting doses with gradual titration are recommended
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drug spending is projected to grow by another 9% to 11% in 2025
GLP-1RA-induced microbial shifts also attenuate chronic low-grade systemic inflammation by reducing pro-inflammatory cytokines, including tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), which supports muscle protein integrity and recovery [154,155]
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