novo nordisk oral glp-1 applies to FDA for cardio label expansion of Rybelsus FDA approves first-ever oral GLP-1

Initial observations in both rodent [with ISO (134)] and NHP [with ISO (135) and KET (136, 137)] models demonstrated dramatic elevations of both activated caspase-3 and cell death markers following GA exposure, which was found to be as much as 13-fold higher than control animals

While there is one oral version of semaglutide currently available on the market, its results have been inferior to the injectable alternatives

Scand.J Clin Lab Invest 1985;45(3):193-198

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