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Anti-obesity and glucose-lowering pharmacotherapies predominantly exert their actions by inducing satiety (liraglutide, setmelanotide, lorcaserin, pramlintide, sibutramine) or by inducing malabsorption of nutrients (orlistat)

Chronic illness, like diabetes, can also interfere, partly because diabetes is associated with higher rates of obesity and PCOS, which are both factors causing irregular periods