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Starting at low doses (100250 mcg) and titrating up helps manage this

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You should also seek medical advice if you experience signs of skin infection , such as increased redness, warmth, swelling, pus formation, or fever

The study concluded that while PR-104 demonstrated biological proof-of-principle for targeting hypoxia and metabolic vulnerabilities in leukemia, its clinical use is constrained by toxicity, supporting the need for biomarker-guided selection and combination approaches rather than monotherapy (281)