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Some patients also report reduced food intake leading to lower core body temperature throughout the day
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The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models
It was developed chemically from NVP DPP728 and therefore also a cyanopyrrolidide compound (22, 50)
