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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (47) and small early-phase clinical trials (8, 9)

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Most available products are marketed as research chemicals or for laboratory use only. This creates significant and very real risks: Contamination and impurity : Products from unverified vendors may contain impurities, incorrect concentrations, or even entirely different compounds than whats advertised on the label

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