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An important consideration is that most individuals with BN are not obese, which means that the attenuated GLP-1 response in BN cannot be attributed to obesity-related GLP-1 blunting and may instead reflect disorder-specific physiological alterations
This approach minimizes gastrointestinal adverse effectsthe most common reason for treatment discontinuationby allowing the body to adapt to increasing GLP-1 and GIP receptor activation
This prevents medication from leaking back through the needle track, which causes surface irritation and wastes medication
Rosenstock stated in the Regeneron press release: "These complete 26-week COURAGE results demonstrate a meaningful opportunity to preserve muscle mass while enhancing fat loss." Also noted: "Numerical improvements in metabolic and lipid parameters, secondary and exploratory endpoints, were seen across all treatment groups, including improvements in waist circumference, blood pressure, cholesterol, triglycerides and A1C." Read the full press release: #ClinicalResearch #Obesity #GLP1 #semaglutide Interesting early results
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