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Semaglutide and tirzepatide, available through licensed 503A compounding pharmacies at PlexusDx, work by activating GLP-1 receptors in the brain to reduce hunger signals and increase feelings of fullness
Why it matters: Dehydration worsens constipation, fatigue, and can be dangerous if you're also experiencing vomiting or diarrhea
It also needs to be taken daily versus the weekly injections
Retatrutide is not expected to be available before the second half of 2027 at the earliest, and realistically mid-2028 meaning a wait of a year or more from today
A previous study from 2024 found participants prescribed semaglutide for diabetes were four times more likely to develop NAION
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