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Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA
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In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig
Its selective mechanism reduces the risk of hormonal imbalances
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