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While GLP-1s are mainly known for their impact on glycaemic control and weight management, they play a role beyond, with effects confirmed or at least suspected on cardiovascular risk, kidney disease, obstructive sleep apnoea and osteoarthritis
JJH has served on scientific advisory panels and received speaker fees for Novo Nordisk
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Higher-End Protocol (Intensive Research): In some specific, intensive research scenarios, dosages might go up to 1,000 mcg (1 mg) per day, usually split into two 500 mcg doses
While GLP-1 therapies may reduce long-term risks of cardiovascular disease, diabetes complications, and disability, those benefits often accrue over decadeswell beyond the timeframe relevant to most employer plan sponsors
