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ODriscoll histological assessment Histological findings ( n = 8 at each time point) for each section were evaluated and scored by three investigators according to ODriscoll histological grading parameters (cell morphology, matrix staining, structural integrity, thickness/defect filling, osteochondral junction, adjacent bonding, basal integration, cellularity, clustering/distribution, and adjacent cartilage) to quantitatively evaluate the extent of cartilage repair based on the criteria of predominant tissue type, structural properties, freedom from degenerative changes in the neighboring cartilage, and freedom from cellular changes of degeneration [26]
This effect is particularly important in heart failure models, where fibrosis reduces cardiac elasticity and contractile ability (Zhang et al., 2021)
Schedule: Daily subcutaneous injections for 812 weeks, optionally extended to ~16 weeks for longer research goals
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