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Lactylation in other diseases Lactylation of histones and non-histone proteins is also linked to other various diseases, including liver diseases such as fibrosis, liver ischemia/reperfusion injury (LI/R) injury, and acetaminophen (APAP)-induced liver injury (AILI), lung fibrosis, acute and chronic kidney injuries, skin injuries such as flap necrosis and hyperplastic scarring, skeletal issues such as osteoarthritis and intervertebral disc degeneration (IDD), and sHLH (Figs

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GLP-1s are on a high and not going anywhere Public awareness and patient adoption of GLP-1 and gastric inhibitory polypeptide (GIP) agonists have grown in the past couple of years as these medications evolved from Type 2 diabetes treatments to highly effective weight loss drugs approved by the Food and Drug Administration (FDA)

to correct both the hyperglycemia and the metabolic derangement causing ketoacidosis Hyperosmolar hyperglycemic non-ketotic state in Type 2 diabetes Infections and poor wound healing in all diabetics In type 2 diabetes complications are present in approximately 50% of patients at the time of diagnosis