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GLP-1RAs consistently reduce energy consumption and modulate reward-related behaviors by suppressing neurocortex activation in response to higher rewards and food cues, especially to high-calorie foods, as well as reducing calorie intake and hunger levels

The exact mechanism is not fully understood, but gastrointestinal effects and possible changes to saliva composition may contribute to metallic, bitter, or unpleasant taste sensations

These may include redness, swelling, itching, or mild pain at the injection site

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There can be tolerance with repeated use, which degrades efficacy and increases doses, leading to safety concerns