The onset and progression of prostate cancer could be prevented by changing dietary habits by modulating nuclear factor-kappa B (NF-B), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), Akt, extracellular signal-regulated kinase (ERK), and phosphoinositide 3-kinases (PI3K) signaling pathways
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The drug lowered levels of 2-aminoadipic acid (2-AAA), triglycerides (TGs) enriched in short- and saturated-chain fatty acids, and urate in both trial populations, while 2-hydroxybutyrate (2-HB) was lowered more robustly in the T2D cohort and mainly by week 48 in the obesity trial