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Further investigation revealed that the dosage of the L-glutathione administered to the patients contained excessive bacterial endotoxin, with some results as high as five times the appropriate limit

At the sites of damaged or dying cells caused by trauma or an infection, free AIM released from IgM can bind dead cell debris which contains damage-associated molecular patterns (DAMPs), thereby promoting the internalisation of dead cells by phagocytes 3,20,21