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While short-term efficacy is well-documented, concerns remain about the long-term impact of prolonged GLP-1 receptor activation, particularly in non-diabetic populations

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At the same time, melatonin treatment significantly inhibited the oxaliplatin-induced increase in the mRNA expression of cytokines such as interleukin-1 (IL-1), tumor necrosis factor- (TNF-), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1) in the spinal dorsal horn [48]

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