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[8] [20] Beyond nausea, patients commonly experience a constellation of gastrointestinal symptoms including: Vomiting (reported in 24% of semaglutide users) Diarrhea (affecting 30% of patients) Constipation (occurring in 24% of users) Abdominal pain or discomfort (experienced by 20% of patients) Bloating and excessive gas Acid reflux or heartburn Decreased appetite (which, while therapeutic, can feel uncomfortable) The severity of these symptoms typically ranges from mild to moderate, and most patients do not discontinue treatment due to nausea alone

doi: 10.2337/dc16-0046 58 GarveyWTBirkenfeldALDickerDMingroneGPedersenSDSatylganovaAet al

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Renowned for its ability to replenish levels of the antioxidant glutathione, it also regulates the important neurotransmitter glutamate