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Patients who experience nausea or other gastrointestinal symptoms at standard starter doses often tolerate low-dose protocols better, which can improve adherence and long-term outcomes

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A crucial role is played by endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) that act on O 2 and H 2 O 2 , respectively, as well as glutathione peroxidase (Gpx) that uses GSH as co-substrate (Fu and Chung 2018)

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