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The study received funding support from the National Institutes of Diabetes and Digestive and Kidney Diseases (K01 DK132461, R01 DK123075, DK125353, DK046492), the European Research Council (no.695054), the German Research Foundation (DFG TRR296, TRR152, SFB1123 and GRK 2816/1), the German Center for Diabetes Research, the European Research Council (no.101044445), the Helmsley Charitable Trust Foundation, and investigator-initiated grants from Eli Lilly, Novo Nordisk, and Proteostasis

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