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The EMA committee specifically found methodological issues in studies that had claimed a link and concluded there was no causative proof ( [147] ) ( [148] )

The FDA cited concerns including potential heart-related adverse events in available safety data and the general Category 2 rationale of insufficient safety information for compounding

Subsequently, the mice were randomly assigned to either a normal chow diet (NCD, n = 6) or a high-fat diet (HFD, n = 12

This hormone helps regulate blood sugar and appetite