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Several studies have investigated the potential therapeutic implications of reducing homocysteine levels in diabetic retinopathy
Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees
However, split-dosing protocols for similar incretin-based peptides show that dividing the dose does reduce peak blood levels by approximately 15-25%, which correlates with reduced gastrointestinal side effects in some individuals
European Journal of Clinical Investigation , 1994, 24:600-6