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The combination creates a powerful, synergistic effect that no single peptide can replicate

A 2012 paper by Pickart, Vasquez-Soltero, and Margolina published in Oxidative Medicine and Cellular Longevity examined the tripeptides role in limiting oxidative stress associated with aging tissue, proposing mechanisms relevant to degenerative processes beyond skin alone (PMID 22666519)

2. Hydration architecture (optical smoothing)

10.1097/MD.0000000000016163 201 HuangY

We can indirectly assume ozone therapy influenced synthesis and release of cytokines (18,19) in such a way that a change from Th2 to Th1 (IL-2, IFNg) cytokine pattern occurs, or ozone therapy acted as Th2 cytokine inhibitor