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Furthermore, treatment for 1 h with exendin-4 reduced the expression of the pro-inflammatory cytokines, TNF and MCP-1, in response to lipopolysaccharide (LPS) (188)
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One study found that 10% muscle mass loss over 68 weeks on a GLP-1 equaled roughly two decades of normal age-related muscle decline
Our findings demonstrate that not all DM2 therapies offer equal neuroprotective benefits, highlighting the need for precision medicine strategies that integrate metabolic, genetic, and environmental factors to optimize treatment selection for individuals at risk of comorbid AD in DM2
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