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Second, published human clinical-trial data is sparse

Front Endocrinol 10:431 Zhang Y, Han S, Kong M, Tu Q, Zhang L, Ma X (2021) Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration

The normalized ChIP reads in gene bodies relative to all aligned reads are shown for the middle and bottom tercile in terms of gene expression (as determined by RNA-seq RPKM levels across all condition) are shown (lower)

It does not say tirzepatide causes birth defects in humans

Acceptance of these conclusions, of course, requires reconciliation with the finding that multiple mitochondrial respiratory complex subunits exhibited decreased expression in treated animals