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Notably, we recently demonstrated that HITI outperforms HDR in terms of knock-in efficacy for GFP gene at the Alb locus in mouse hepatocyte when using clinically relevant, lipid nanoparticle (LNP)-based deliver systems
In addition, reactions (rash or itching) at the injection site, insomnia, dizziness, and fatigue may occur
This can lead to aching, leg swelling, heaviness, and throbbing in the legs
This effect of PCSK9 leads to a reduced ability of the liver to remove IDL and LDL from the blood contributing to the potential for hypercholesterolemia
Mody, R
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