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In the absence of functional GNE, IGF-1R was hyposialylated and transduced a downstream signal upon IGF-1 (IGF-1R ligand) treatment
Ipamorelin is notable for its selectivity, unlike other GHS-R agonists, research indicates it produces minimal effects on ACTH, cortisol, or prolactin in research models (Raun et al., Endocrinology, 1998)
The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
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