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The idea behind microdosing is pretty simple: you may not need the highest dose to make meaningful progress
Similar to patients with MASH and obese individuals who exhibit increased circulating FGF21 levels, an increase in plasma FGF21 concentrations has been reported in DIO mice, which also exhibit FGF21 resistance due to desensitization of FGFR1/KLB signaling [38]
Wang L, Zehir A, Sadowska J
They counteract the imbalance between bone production and resorption that is typical in type 2 diabetes by promoting bone formation and enhancing blood supply to bones
Some newer studies have explored spacing injections every two weeks for maintenance rather than continuing weekly doses indefinitely
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