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AOD9604 and Cartilage Biology Research In a collagenase-induced knee osteoarthritis rabbit model, intra-articular injection of AOD9604 significantly enhanced cartilage regeneration compared to saline controls, with combined AOD9604 and hyaluronic acid injections proving more effective than either treatment alone producing superior morphological and histopathological scores and a significantly shorter lameness period in the AOD9604 + HA group
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In addition, dichloroacetic acid (DCA), a pyruvate dehydrogenase activator, enhanced cardiac efficiency during IRI of isolated rat hearts by increasing glucose oxidation (59)
Structure determination was initially performed by molecular replacement in Phaser 28 using a search model generated by Alphafold2 25
