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Clinical studies show that GLP-1 receptor agonists produce meaningful weight loss across diverse populations, with the FDA approving semaglutide for weight management in adults with a body mass index (BMI) of 30 or higher, or 27 or higher with weight-related health conditions

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The effects of Exendin-4 were abolished in the presence of Exendin (939), but remained intact when insulin secretion was abrogated by diazoxide (Fig