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Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase

Discontinue use and consult a healthcare provider if any unusual symptoms appear

All laboratory analyses were conducted at the accredited laboratory of Tartu University Hospital using standard techniques

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Drink at least 810 glasses of water daily, and increase intake on injection days or when headaches begin