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In the context of sepsis, experimental studies have demonstrated that adiponectin deficiency exacerbates inflammation, promotes leukocytes and platelet adhesion, and compromises bloodbrain barrier integrity, partly through the upregulation of E-selectin

If a dose increase causes intolerable GI symptoms, the Phase 2 protocol explicitly permitted returning to the prior dose level and waiting a full 4 weeks before re-attempting escalation

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Importantly, they noted that these mental health improvements had not occurred when they had achieved this level of weight loss in the past through other means e.g

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