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Metabolic control of outpatients with T1DM Several groups from Italy, Spain and the UK have reported that patients with T1DM and without COVID-19 have shown no deteriorations in glycaemic control, and often even show improvements in control, during the pandemic compared with a control period before the pandemic 131,132,133

The presence of GLP-1 (GLP-1R) and GIP receptors (GIP-R) suggest direct interaction of these agents with EAT

Typical dosing: Daily, gradually titrated Common side effects: Nausea, headache, constipation, sleep changes Important note: Non-stimulant option, but not appropriate for some medical conditions or medication histories

This is mechanistically distinct from amphetamine-class compounds: tesofensine doesn't release stored catecholamines

"It actually changes peoples moles in general