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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

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By preventing nicotinamide from being methylated away, more of it is available for the NAD+ salvage pathway, so intracellular NAD+ rises

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