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In a rat model of spinal nerve ligation (SNL), exenatide significantly enhanced the expression of M2 microglial markers, including IL-10, IL-4, Arg1, and CD206, in both spinal microglia and primary cultured microglia [63]
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While highly promising, the above studies have involved small sample sizes with durations of less than one month
Higher exposure and a smaller fat reserve suggest greater side-effect and lean-mass risk, but no long-term trial has measured the outcome
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